1 2 3 4 5 Controlling instabilities in manipulation requires specific cortical - striatal - cerebellar 6 networks 7 8 9
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چکیده
44 Dexterous manipulation requires both “strength”, the ability to produce fingertip 45 forces of a specific magnitude; and “dexterity”, the ability to dynamically regulate the 46 magnitude and direction of fingertip force vectors and finger motions. While cortical 47 activity in fronto-parietal networks has been established for stable grip and pinch forces, 48 the cortical regulation in the dexterous control of unstable objects remains unknown. We 49 employed functional magnetic resonance imaging (fMRI) to interrogate cortical networks 50 engaged in the control of four objects with increasing instabilities but requiring constant 51 strength. In addition to expected activity in fronto-parietal networks we find that 52 dexterous manipulation of increasingly unstable objects is associated with a linear 53 increase in the amplitude of the BOLD signal in the basal ganglia (p = 0.007 and p = 54 0.023 for two compression tasks). A computational regression (connectivity) model 55 identified independent subsets of cortical networks whose connection strengths were 56 mutable and associated with object instability (p< 0.001). Our results suggest that in the 57 presence of object instability, the basal ganglia may modulate the activity of premotor 58 areas and subsequent motor output. This work, therefore, provides new evidence for the 59 selectable cortical representation and execution of dynamic multifinger manipulation for 60 grasp stability. 61 62
منابع مشابه
Neurophysiol Francisco J . Valero - Cuevas Kristine Mosier , Chad Lau , Yang Wang , Madhusudhan Venkadesan and specific cortical - striatal - cerebellar networks Controlling instabilities in manipulation requires
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Controlling instabilities in manipulation requires specific cortical-striatal-cerebellar networks.
Dexterous manipulation requires both strength, the ability to produce fingertip forces of a specific magnitude, and dexterity, the ability to dynamically regulate the magnitude and direction of fingertip force vectors and finger motions. Although cortical activity in fronto-parietal networks has been established for stable grip and pinch forces, the cortical regulation in the dexterous control ...
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تاریخ انتشار 2011